Pyridines and derivatives

Aromatic organic compounds consist of an aromatic six-membered ring containing one nitrogen atom and five carbon atoms; includes compounds derived from pyridines.

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6,046 – 6,060 of 178,527 results

6,046

Apexbio Technology LLC Beclomethasone dipropionate 5534-09-8 50mg

Beclomethasone dipropionate (CAS 5534-09-8) is a small-molecule agonist targeting glucocorticoid receptors It is designed to modulate glucocorticoid receptor activity thereby suppressing inflammatory responses Beclomethasone dipropionate exerts its biological activity primarily through binding to glucocorticoid receptors leading to modulation of gene expression and inhibition of inflammatory mediator release Based on these pharmacological properties beclomethasone dipropionate holds research potential in the study of respiratory conditions such as asthma and allergic rhinitis as well as in evaluating glucocorticoid receptor interactions and therapeutic response in preclinical and clinical models

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6,047

Medchemexpress LLC MMP-9-IN-9 10mg | 206549-55-5 | 511.63 | C27H33N3O5S | 10 MG

MMP-9-IN-9 is a selective small-molecule inhibitor of matrix metalloproteinase-9 (MMP-9) for research use. It exhibits potent inhibition of MMP-9 (IC50 ≈ 5 nM), shows selectivity versus other MMPs, is supplied as a white to off-white solid, and is typically dissolved in DMSO for in vitro studies. Recommended storage for the powder is -20°C.

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6,048

Medchemexpress LLC Angiopoietin-related protein 7 (canine), recombinant | >95.0% | 10 UG

Recombinant canine angiopoietin-related 7 (ANGPTL7) protein expressed in HEK293 cells and supplied with a C-terminal 6xHis tag. The product corresponds to amino acids Q27-P344, has an approximate molecular weight of ~35 kDa, and a purity of >95% by reducing SDS-PAGE. Supplied as 10 μg; freeze aliquots at -20 °C or -80 °C for long-term storage.

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6,049

Medchemexpress LLC RBN-2397 | 2381037-82-5 | >99.8% | 523.43 | 1 ML

RBN-2397 is a potent, orally active, and across-species NAD+ competitive inhibitor of PARP7 (IC50<3 nM). It selectively binds to PARP7 (Kd=0.001 μM) and restores IFN signaling. RBN-2397 has potential for the study of advanced or metastatic solid tumors. It inhibits cell proliferation with an IC50 value of 20 nM in NCI-H1373 lung cancer cells and shows a restoration of type I IFN response by increasing STAT1 phosphorylation in NCI-H1373 human lung cancer cells. It also inhibits cell MARylation with an EC50 value of 1 nM.

Induces tumor-specific adaptive immune memory in a CT26 syngeneic model
Causes complete regressions at a dose of 100 mg/kg
Exerts dose-dependent effects on tumor growth
Half-life (t1/2) in vivo is 325 minutes

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6,050

Medchemexpress LLC 2,2'-Azobis(2-methylpropionamidine) dihydrochloride | 2997-92-4 | MFCD00142725 | 98.0% | 271.19 g/mol | C8H20Cl2N6 | 1g

AAPH (2 2 -Azodiisobutyramidine dihydrochloride) has an effect of radical generation AAPH induces oxidative stress and erythrocyte hemolysis[1] AAPH decomposes at 37 to generate an alkyl radical is used as an initiator In the presence of oxygen these alkyl radicals will be converted to peroxyl radicals that can cause lipid peroxidation and loss of erythrocyte membrane integrity which could ultimately lead to hemolysis[1][2][3][4]

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6,051

Bioss Neisseria menengitidis

Neisseria menengitidis

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6,052

Medchemexpress LLC Finerenone (standard) | 1050477-31-0 | 99.59% | 378.42 | 25 MG

Finerenone (standard) | 1050477-31-0 | 99.59% | 378.42 | 25 MG

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6,053

Medchemexpress LLC Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate | 1928763-08-9 | 99.8% | 1 ML

ML418 is a potent, selective potassium channel blocker used for research on Kir7.1. Supplied as high-purity powder or as a ready-to-use 10 mM solution in DMSO (1 mL), it is intended for in vitro screening and CNS pharmacology studies.

Potent Kir7.1 potassium channel blocker.
High purity (≈99.8%) supporting reliable biological data.
Available as powder and as a 10 mM DMSO solution for convenience.
Molecular weight 377.87 and formula C19H24ClN3O3.
Store powder and solutions under recommended cold conditions to preserve stability.

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6,054

Medchemexpress LLC 3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro... | 17617-45-7 | 99.9% | 25 MG

Picrotoxinin is a potent convulsant and chloride channel blocker that acts as a noncompetitive GABAA receptor antagonist. It negatively modulates the action of GABA on GABAA receptors, specifically inhibiting the α1β2γ2L GABAA receptor.

Potent convulsant
Chloride channel blocker
Noncompetitive GABAA receptor antagonist
Modulates GABA action on GABAA receptors
Inhibits α1β2γ2L GABAA receptor

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6,055

Apexbio Technology LLC 2'-F-dCTP(Synonyms: 2'-Fluoro-2'-deoxycytidine-5'-triphosphate, 2'-Fluoro-dCTP, 2'-F-2'-deoxycytidine triphosphate), 10ul (100 mM).

2 -F-dCTP is a small molecule analog of deoxycytidine triphosphate that exerts its biological effects primarily through modulation of nucleotide metabolic pathways It is known to interfere with specific molecular signaling cascades and enzymatic activities involved in DNA synthesis and metabolism Due to its ability to stably modulate the activities of relevant biological targets 2 -F-dCTP has been utilized in biomedical research to investigate and disrupt metabolic pathways linked to disease mechanisms aiding in the identification of novel therapeutic approaches

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6,056

Medchemexpress LLC Recombinant human TRIB3 protein (GST-tagged) | >90.0% | 10 UG

Recombinant human TRIB3 protein with an N-terminal GST tag, produced in Sf9 insect cells and supplied as a 10 μg vial for laboratory research. The protein is provided in a Tris-buffered, glycerol-containing solution and is intended for research use only.

Expressed in Sf9 insect cells with an N-terminal GST tag.
Available as a 10 μg vial.
Purity >90% by reducing SDS-PAGE.
Apparent molecular weight ~65.8 kDa.
Supplied in 50 mM Tris, 100 mM NaCl, pH 8.0, 10% glycerol, 0.5 mM reduced glutathione.
Store at -80°C and avoid repeated freeze-thaw cycles.

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6,057

Medchemexpress LLC Jak-in-1 | 1334673-53-8 | 98.4% | 380.44 | 100 MG

JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8, and 3.2 nM, respectively. It exhibits improved selectivity for JAK3 over JAK1. This compound inhibits the proliferation of human CD4 and CD8 T cells in a dose-dependent manner upon stimulation and is active in both mechanistic and functional cell-based assays using T-cells. In vivo, it is JAK3 selective, potently inhibits IL-2 stimulated plasma concentrations, and prevents IL-2-driven STAT5 phosphorylation.

Inhibits proliferation of human CD4 and CD8 T cells in a dose-dependent manner.
Active in both mechanistic and functional cell-based assays using T-cells.
Exhibits JAK3 selectivity in vivo.
Potently inhibits IL-2 stimulated plasma concentrations.
Prevents IL-2-driven STAT5 phosphorylation in a dose- and concentration-dependent manner.

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6,058

BIOHIPPO RLuc-BSD LV

RLuc-BSD is a transcription factor reporter lentiviral vector designed to monitor the target signaling pathway in living cells The construct carries a fluorescent reporter gene under the control of pathway responsive elements and includes a blasticidin selection marker to generate stable cell pools The lentivirus is provided as a ready to use VSV G pseudotyped preparation for efficient gene delivery and stable genomic integration Each vial provides a nominal titer of 5x10E6 transducing units TU Typical applications include pathway activation studies assay development compound screening and mechanism of action research The system is suitable for human and mouse cells and can be read using standard fluorescence microscopy flow cytometry or luciferase assays depending on the reporter gene This product is intended for research use only and is not for diagnostic or therapeutic procedures

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6,059

BIOHIPPO AAV-GFaABC1D-CRF1.0

Recombinant adeno associated virus expressing CRF1.0 under the GfaABC1D promoter. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.

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6,060

Apexbio Technology LLC Lactacystin (Synthetic) 133343-34-7 500ug

Lactacystin (Synthetic) is an irreversible proteasome inhibitor that selectively targets the catalytic subunits of the 20S proteasome inhibiting chymotrypsin-like trypsin-like and caspase-like enzymatic activities It exhibits an IC50 of approximately 4 8 M Lactacystin has been widely utilized as a research tool to study proteasome-mediated biological pathways Experimentally Lactacystin administration triggered neurite extension and transient cAMP elevation in Neuro-2a cells and induced cell-cycle arrest in MG-63 osteosarcoma cells In animal glioma xenograft models Lactacystin treatment at doses ranging from 1 to 5 g per 20 g body weight reduced tumor volume demonstrating its potential application in glioma research

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Pyridines and derivatives

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Apexbio Technology LLC Beclomethasone dipropionate 5534-09-8 50mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC MMP-9-IN-9 10mg | 206549-55-5 | 511.63 | C27H33N3O5S | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Angiopoietin-related protein 7 (canine), recombinant | >95.0% | 10 UG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC RBN-2397 | 2381037-82-5 | >99.8% | 523.43 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 2,2'-Azobis(2-methylpropionamidine) dihydrochloride | 2997-92-4 | MFCD00142725 | 98.0% | 271.19 g/mol | C8H20Cl2N6 | 1g Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Finerenone (standard) | 1050477-31-0 | 99.59% | 378.42 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate | 1928763-08-9 | 99.8% | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro... | 17617-45-7 | 99.9% | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC 2'-F-dCTP(Synonyms: 2'-Fluoro-2'-deoxycytidine-5'-triphosphate, 2'-Fluoro-dCTP, 2'-F-2'-deoxycytidine triphosphate), 10ul (100 mM). Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Recombinant human TRIB3 protein (GST-tagged) | >90.0% | 10 UG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Jak-in-1 | 1334673-53-8 | 98.4% | 380.44 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

BIOHIPPO RLuc-BSD LV Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

BIOHIPPO AAV-GFaABC1D-CRF1.0 Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Lactacystin (Synthetic) 133343-34-7 500ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More